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KMID : 0882420110800020238
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Korean Journal of Medicine
2011 Volume.80 No. 2 p.238 ~ p.242
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An Adrenocorticotropic Hormone-secreting Malignant Pancreatic Neuroendocrine Tumor
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Song Eun-Mi
Lee Kyong-Eun
Jo Jung-Youn
Koo Hea-Soo
Choi Moon-Young
Seong Chu-Myong
Lee Soon-Nam
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Abstract
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Pancreatic endocrine tumors are low-to-intermediate-grade neoplasms arising from the pancreatic islets that produce various hormones. These tumors account for a minority of pancreatic tumors and are generally considered functional if they are associated with a hormonal syndrome. Adrenocorticotropic hormone-secreting tumors (ACTHomas) are very rare and require special clinical consideration. Patients with ACTH-secreting tumors usually present with Cushing’s syndrome, due to ectopic ACTH production. ACTHomas have a poor prognosis because of early metastasis and difficulty controlling corticosteroid production. We report a 62-year-old male with an ACTH-secreting metastatic pancreatic neuroendocrine tumor, who did not respond to somatostatin analogs and died.
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KEYWORD
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ACTH-secreting, Neuroendocrine tumor, Pancreas
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